The mutants develop detectable head-tilt and slight tremor by weaning age (average onset 16 +/- 3 days). Mutants of either gender have been produced and homozygotes are viable. Detailed whole ear histology on 1 mutant (age 48 days) showed saccular and utricular otoconia; no labyrinth malformation was observed. Standard pathology work-up on 3 other mutants (age 20 days) showed the thymus had a thin, atrophic cortex with few lymphocytes and some apoptosis; the spleen was very small. Standard eye histology on one mutant and one control littermate (age 29 days) showed no abnormalities.
Please note: The majority of frozen NMF embryos is obtained through matings between homozygous (or heterozygous) mutant males and wild-type females; if recovery of mutants is requested, the mice will be shipped as soon as possible following wean without further phenotype or genotype testing. NMF embryos are supplied subject to the General Terms and Conditions of Sale posted at www.jaxmice.jax.org. For prices or further information, please inquire at srp@jax.org or nmf-mice@jax.org. (19) NMF4 have been requested by and distributed to 4 investigators.
