|
| MUTANT LINE 7TNJ |
Contact TMGC for ordering information
|
| Synopsis: |
|
Increased locomotor activation following ethanol administration. |
| Detailed Phenotype Description: |
|
This autosomal recessive mutation (tmgc12), linked to distal Chr 15, was detected in the progeny of C57BL/6JRn males given a single dose of 200 mg/kg ENU. The mutation is maintained on a segregating C3H:B6 background. The 7TNJ pedigree exhibits high levels of locomotor activity in an activity chamber following a dose of 2.25 g/kg of ethanol. The mice are placed in the activity chamber 15 min. after an IP injection of ethanol and the behavior is recorded for a total of 10 minutes. This abnormal locomotor activity has been confirmed in least 2 generations of mice from this pedigree. The mean for this activity measure (total distance traveled) was over 4.7 SD above the population mean. This behavior is not a result of abnormal ethanol metabolism as blood ethanol concentrations were normal in this pedigree of mice. Subsequent expanded testing examining baseline as well as ethanol-induced locomotor activity at 2 ethanol doses indicated that no baseline differences were observed but the ethanol-induced locomotor activation was found only at the 2.25 g/kg dose of alcohol and not at a lower dose of 1.5 g/kg.
Detailed data sheet
|
| Abnormal Assays: | Domain(s): |
| Alcohol-influenced activity (view protocol) |
Alcohol Abuse,
Movement/Neuromuscular Function
|
|
|
MUTANT LINE INFORMATION |
Mutant Line Name
| 7TNJ (view more detail at Mutagenesis Center) |
| Gene Symbol |
tmgc12
(view more info on gene)
|
| Gene Name |
Tennessee Mouse Genome Consortium 12 |
| Allele Symbol |
tmgc12 |
| Allele Name |
Tennessee Mouse Genome Consortium 12 |
| MGI ID |
MGI:2448638 (view MGI record) |
| Originating Mutagenesis Center |
Tennessee Mouse Genome Consortium (contact for ordering information) |
| Mutation Type |
chemically induced mutation (CI)
|
| Strain Designation |
C3H/Rl;B6-tmgc12 |
| Data Sheet |
view data sheet |
|
|
HERITABILITY AND MAPPING INFORMATION |
| Background Strain |
Segregating C3H/Rl and C57BL/6JRn |
| Mode of Inheritance |
Recessive |
| Heritability |
Proven (Segregation In Progress, view detail) |
| Chromosome Location |
15 |
| Mapping Interval |
|
| Identified Mutation |
|
|
|
STATUS INFORMATION |
| Availability |
|
| Confirmation Date |
30-Apr-2002 |
| Availability Date |
14-Nov-2002 |
| Off-Shelf Date |
|
| Line History Comments |
(3) 7TNJ have been requested and distributed to investigators. |
