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| MUTANT LINE 71TNP |
Contact TMGC for ordering information
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| Synopsis: |
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Wide-range frequency hearing loss in Male mice. |
| Detailed Phenotype Description: |
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This autosomal recessive mutation (tmgc37), linked to mid Chr7, was detected in the progeny of non-inbred D7R75M males given one dose of 125 mg/kg ENU. A total of 43 animals, representing 5 generations and aged between 6-11 weeks, in the 71TNP pedigree were tested for hearing performance by auditory brainstem response (ABR). Although no significant hearing loss was observed at any frequencies when both males and females were combined (less than 1.8 x SD), this pedigree showed significant hearing loss at all frequencies when only males (25-28 mice) were analyzed (see figure). To compare to all other TNP pedigrees containing tested males (27-53 pedigrees and 188-279 males), ABR thresholds of 71TNP males are elevated significantly at 8 kHz (2.4 x SD) and 16 kHz (2.7 x SD), but insignificantly at click (1.1 x SD) and 32 kHz (1.6 x SD). This pedigree represents a model for high frequency hearing loss in humans, a common condition among people with various hearing disorders at various ages.
Detailed data sheet
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| Abnormal Assays: | Domain(s): |
| Auditory brain stem response (ABR) (view protocol) |
Auditory/Vestibular
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MUTANT LINE INFORMATION |
Mutant Line Name
| 71TNP (view more detail at Mutagenesis Center) |
| Gene Symbol |
tmgc37
(view more info on gene)
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| Gene Name |
Tennessee Mouse Genome Consortium 37 |
| Allele Symbol |
tmgc37 |
| Allele Name |
Tennessee Mouse Genome Consortium 37 |
| MGI ID |
MGI:3053561 (view MGI record) |
| Originating Mutagenesis Center |
Tennessee Mouse Genome Consortium (contact for ordering information) |
| Mutation Type |
chemically induced mutation (CI)
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| Strain Designation |
STOCK 71TNP |
| Data Sheet |
view data sheet |
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HERITABILITY AND MAPPING INFORMATION |
| Background Strain |
Mixed, noninbred |
| Mode of Inheritance |
Recessive |
| Heritability |
Proven (Segregation In Progress, view detail) |
| Chromosome Location |
7 |
| Mapping Interval |
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| Identified Mutation |
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STATUS INFORMATION |
| Availability |
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| Confirmation Date |
20-Nov-2003 |
| Availability Date |
18-Jan-2004 |
| Off-Shelf Date |
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| Line History Comments |
(1) 71TNP have been requested and distributed to investigators. |
