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| MUTANT LINE 138TNR |
Contact TMGC for ordering information
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| Synopsis: |
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Females of 138TNR consume high amounts of ethanol in part due to high consumption of liquid. |
| Detailed Phenotype Description: |
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This recessive mutation (tmgc50), linked to Chr 15, was detected in the progeny of C57BL/6JRn males given one dose of 150 mg/kg ENU. 138TNR females exhibits increased ethanol consumption in a standard two-bottle choice test in which mice are given 2 bottles, one containing a 10%(v/v) ethanol solution in water and the other containing just water. The amount of each solution that is consumed is measured and recorded each day for the 4-day trial. In particular, the grams of ethanol consumed per kilogram of mouse are high (See BOTTLE_ETHA_DAY) as is the amount of ethanol consumed in mls (see BOTTLE_ETHANOL). However, the amount of water consumed is not low (see BOTTLE_WATER) nor is the preference ratio (see BOTTLE_PREF_RAT) particularly high suggesting that these mice consume large amount liquid. Genetic control of gender-specific ethanol consumption has been shown in several studies through the use of QTL analyses.
Detailed data sheet
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| Abnormal Assays: | Domain(s): |
| Two-bottle ethanol-choice test (view protocol) |
Alcohol Abuse,
Gustation/Olfaction
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MUTANT LINE INFORMATION |
Mutant Line Name
| 138TNR (view more detail at Mutagenesis Center) |
| Gene Symbol |
tmgc50
(view more info on gene)
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| Gene Name |
Tennessee Mouse Genome Consortium 50 |
| Allele Symbol |
tmgc50 |
| Allele Name |
Tennessee Mouse Genome Consortium 50 |
| MGI ID |
MGI:3589249 (view MGI record) |
| Originating Mutagenesis Center |
Tennessee Mouse Genome Consortium (contact for ordering information) |
| Mutation Type |
chemically induced mutation (CI)
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| Strain Designation |
STOCK 138TNR |
| Data Sheet |
view data sheet |
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HERITABILITY AND MAPPING INFORMATION |
| Background Strain |
Mixed, noninbred |
| Mode of Inheritance |
Recessive |
| Heritability |
Proven (Segregation In Progress, view detail) |
| Chromosome Location |
15 |
| Mapping Interval |
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| Identified Mutation |
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STATUS INFORMATION |
| Availability |
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| Confirmation Date |
22-Feb-2005 |
| Availability Date |
22-Mar-2005 |
| Off-Shelf Date |
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| Line History Comments |
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