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| MUTANT LINE 283CH19 |
Contact TMGC for ordering information
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| Synopsis: |
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High frequency hearing loss |
| Detailed Phenotype Description: |
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This autosomal recessive mutation (tmgc52), linked to Chr. 19, was detected in the progeny of C57BL/6-19PWK males given one dose of 150 mg/kg ENU. We have tested a total of 22 to 24 mice representing 5 generations of the 283CH19 pedigree. This pedigree shows significant high-frequency hearing loss at 32 kHz(see Mutant Detail PDF). When compared to all other CH19 pedigrees, ABR thresholds of 283CH19 are elevated significantly at 32 kHz (3.5 x SD), but insignificantly at click (1.0 x SD), 8 kHz (1.3 x SD), and 16 kHz (1.3 x SD). High-frequency hearing loss is very common among human patients with progressive hearing impairment and age-related hearing loss. Thus this mutant could provide a model for such a common disorder.
Detailed data sheet
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| Abnormal Assays: | Domain(s): |
| Auditory brain stem response (ABR) (view protocol) |
Auditory/Vestibular
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MUTANT LINE INFORMATION |
Mutant Line Name
| 283CH19 (view more detail at Mutagenesis Center) |
| Gene Symbol |
tmgc52
(view more info on gene)
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| Gene Name |
Tennessee Mouse Genome Consortium 52 |
| Allele Symbol |
tmgc52 |
| Allele Name |
Tennessee Mouse Genome Consortium 52 |
| MGI ID |
MGI:3589250 (view MGI record) |
| Originating Mutagenesis Center |
Tennessee Mouse Genome Consortium (contact for ordering information) |
| Mutation Type |
chemically induced mutation (CI)
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| Strain Designation |
C57BL/6-19PWK-tmgc52 |
| Data Sheet |
view data sheet |
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HERITABILITY AND MAPPING INFORMATION |
| Background Strain |
C57BL/6-19PWK |
| Mode of Inheritance |
Recessive |
| Heritability |
Proven (Segregation In Progress, view detail) |
| Chromosome Location |
19 |
| Mapping Interval |
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| Identified Mutation |
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STATUS INFORMATION |
| Availability |
- Live mice (LM)
- Cryopreserved sperm (SP)
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| Confirmation Date |
24-May-2005 |
| Availability Date |
22-Aug-2005 |
| Off-Shelf Date |
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| Line History Comments |
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