|
| MUTANT LINE 90TNI |
Contact TMGC for ordering information
|
| Synopsis: |
|
High frequency hearing loss |
| Detailed Phenotype Description: |
|
This autosomal recessive mutation (tmgc53), linked to Chr 10, was detected in the progeny of C3.BLiA males given 150 mg/kg ENU. We have tested a total of 12 mice in only 2 generations of the 90TNI pedigree. This pedigree shows significant high-frequency hearing loss at 32 kHz (Mutant Detail PDF). When compared to all other TNW/I pedigrees, ABR thresholds of 90TNI are elevated significantly at 32 kHz (2.6 x SD), but insignificantly at click (0.1 x SD), 8 kHz (0.8 x SD) and 16 kHz (0.9 x SD). High-frequency hearing loss is very common among human patients with progressive hearing impairment and age-related hearing loss. Thus this mutant could provide a model for such a common disorder.
Detailed data sheet
|
| Abnormal Assays: | Domain(s): |
| Auditory brain stem response (ABR) (view protocol) |
Auditory/Vestibular
|
|
|
MUTANT LINE INFORMATION |
Mutant Line Name
| 90TNI (view more detail at Mutagenesis Center) |
| Gene Symbol |
tmgc53
(view more info on gene)
|
| Gene Name |
Tennessee Mouse Genome Consortium 53 |
| Allele Symbol |
tmgc53 |
| Allele Name |
Tennessee Mouse Genome Consortium 53 |
| MGI ID |
MGI:3589252 (view MGI record) |
| Originating Mutagenesis Center |
Tennessee Mouse Genome Consortium (contact for ordering information) |
| Mutation Type |
chemically induced mutation (CI)
|
| Strain Designation |
STOCK 90TNI |
| Data Sheet |
view data sheet |
|
|
HERITABILITY AND MAPPING INFORMATION |
| Background Strain |
Mixed, noninbred |
| Mode of Inheritance |
Recessive |
| Heritability |
Proven (Segregation In Progress, view detail) |
| Chromosome Location |
10 |
| Mapping Interval |
|
| Identified Mutation |
|
|
|
STATUS INFORMATION |
| Availability |
- Live mice (LM)
- Cryopreserved sperm (SP)
|
| Confirmation Date |
19-Jan-2005 |
| Availability Date |
22-Aug-2005 |
| Off-Shelf Date |
|
| Line History Comments |
|
