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This autosomal recessive mutation (tmgc46), linked to distal Chr15, was detected in the progeny of C57BL/6Jrn males given one dose of 125 mg/kg ENU. A total of 14 animals, representing 3 generations, were tested for hearing performance by auditory brainstem response (ABR). All animals tested demonstrated a profound deafness in response to 32kHz stimuli (i.e. no measurable ABR at the highest SPL tested 95db), and a significantly increased threshold for response to 16kHz and 8kHz stimuli. The pedigree mean values are greater than (or near) the significance level of 1.96SD above the population threshold means for all stimuli tested except for the broadband click stimuli [Mutrack variables: AVE_THRE_32kHz_EAR1, AVE_THRE_16kHz_EAR1, AVE_THRE_8kHz_EAR1]. This pedigree represents a model for high frequency hearing loss in humans, a common condition among people with various hearing disorders at various ages.
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