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| MUTANT LINE 62TNW |
Contact TMGC for ordering information
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| Synopsis: |
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Wide-range frequency hearing loss |
| Detailed Phenotype Description: |
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This autosomal recessive mutation (tmgc54) linked to Chr 10, was detected in the progeny of C57BL/6JRn males given a single dose of 200 mg/kg ENU. The mutation is maintained on a segregating C3.BLiA:C57BL/6 background. We have tested a total of 19 mice in 4 generations of the 62TNW pedigree. This pedigree shows significant hearing loss at all frequencies (Mutant Detail PDF). When compared to all other TNW/I pedigrees, ABR thresholds of 62TNW are elevated significantly at click (4.4 x SD), 8 kHz (4.1 x SD), 16 (4.7 x SD) and 32 kHz (3.3 x SD). Wide-range frequency hearing loss is characteristic of congenital deafness in humans. Thus this mutant could provide a model for such a common disorder.
Detailed data sheet
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| Abnormal Assays: | Domain(s): |
| Auditory brain stem response (ABR) (view protocol) |
Auditory/Vestibular
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MUTANT LINE INFORMATION |
Mutant Line Name
| 62TNW (view more detail at Mutagenesis Center) |
| Gene Symbol |
tmgc54
(view more info on gene)
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| Gene Name |
Tennessee Mouse Genome Consortium 54 |
| Allele Symbol |
tmgc54 |
| Allele Name |
Tennessee Mouse Genome Consortium 54 |
| MGI ID |
MGI:3589253 (view MGI record) |
| Originating Mutagenesis Center |
Tennessee Mouse Genome Consortium (contact for ordering information) |
| Mutation Type |
chemically induced mutation (CI)
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| Strain Designation |
STOCK 62TNW |
| Data Sheet |
view data sheet |
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HERITABILITY AND MAPPING INFORMATION |
| Background Strain |
Mixed, noninbred |
| Mode of Inheritance |
Recessive |
| Heritability |
Proven (Segregation In Progress, view detail) |
| Chromosome Location |
10 |
| Mapping Interval |
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| Identified Mutation |
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STATUS INFORMATION |
| Availability |
- Live mice (LM)
- Cryopreserved sperm (SP)
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| Confirmation Date |
14-Jan-2005 |
| Availability Date |
22-Aug-2005 |
| Off-Shelf Date |
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| Line History Comments |
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