The mutants show body tremor at rest and during movement, and intense trunk swaying, which can impair their ability to stand up-right on their hind limbs. They move around quite well, but draw their hind limbs high and close to their body when walking. This phenotype becomes visible at approximately 4 weeks of age (average 3.8 +/-0.53 weeks; n=41); the mutants breed well and a colony can be maintained through regular breeding. Complementation analysis with Grid2ho-15J (JR#005344; heterozygous x heterozygous matings) resulted in 11 affected mice in a total of 54 progeny demonstrating that nmf408 represents an allele of Grid2. Standard pathology work-up on one mutant (32 days of age) revealed no abnormalities.
Please note:1-This line was detected during behavioral screens for ENU induced mutations but appears to be the result of spontaneous mutagenesis. 2-(2) NMF408 have been requested by and distributed to 1 investigator.
